Nanostructured Modified Electrode for Electrocatalytic Determination of Epinephrine in the Presence of Acetaminophen

In this paper, a nanostructured modified electrode was fabricated by incorporating of 2,2′-[1,9-nonanediylbis(nitriloethylidyne)]-bis-hydroquinone (NNH) as a newly synthesized modifier and TiO2 nanoparticles to the carbon paste (MTCPE) and then was used for the electroanalysis of epinephrine (EP). The electrochemical studies were carried out by using cyclic voltammetry, chronoamperometry and differential pulse voltammetry (DPV) techniques. It has been found that the oxidation of EP at the surface of this electrode occurs at a potential about 235 mV less positive than that of an unmodified carbon paste electrode. A dynamic range of 1.0–2000.0 μM, with a detection limit of 0.37 μM for EP, was obtained using DPV. Also, this modified electrode exhibits well separated oxidation peaks for EP and acetaminophen (AC) using DPV.